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A vaccine prepares the body's immune system to fight off specific pathogens, typically by exposing it to a weakened or inactive form As the pathogen passes between vaccinated hosts, it can gain virulence without killing them — with severe consequences for any. While many vaccines aim to completely block infection and transmission, some function differently
This distinction is relevant when considering how vaccine mechanisms might influence pathogen evolution A leaky vaccine removes this pressure to become less virulent What is a leaky vaccine
A leaky vaccine reduces the.
Leaky vaccines therefore protect subjects with fewer exposures at a higher effective rate than subjects with more exposures This simple observation has serious implications for analysis methodologies that rely on the assumption that the vaccine effect is homogeneous across subjects. Assuming equal exposure in the vaccinated and unvaccinated people, the age distribution of the vaccinated cases will be older than the age distribution of the unvaccinated cases. They allow the spread of deadlier pathogens that would normally burn out quickly
Leaky vaccines are common for animal infections, including marek's disease.
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